Philip Gould’s When I Die: Lessons from the Death Zone (2012), Christopher Hitchens’ Mortality (2012) and Tom Lubbock’s Until Further Notice, I Am Alive (2012) are autopathographies that give utterance to experiences of subjectivity that are increasingly compromised owing to the effects of illness and the knowledge of the irreversibility of the cancer subject’s condition. This essay explores the ways in which cancer subjects represent the processes of defamiliarisation that diagnosis often initiates through three recent autobiographical accounts of men coming to terms with their incurable cancers. For many writing about their experiences of the disease, the ramifications can be multifaceted: robbed of faith in the body’s willingness to bend to regulation, objectified by economically straitened health bureaucracies, trapped in the headlights of mortality, unable to find adequate means for conveying contradictory emotional registers and disabled by others’ fear of the abject, these individuals often understand their subjectivity as inhabiting the liminal space between the human and the creaturely. Conceived of as an unknowable and uncontrollable force from the outside, cancer is paradoxically created within the cancer subject’s own body, a body which profoundly questions the comfortable separation of the human from the animal. Cancer is a disease for which the English language reserves some of its most sinister epithets: cancer is said to ‘devour’, ‘ruin’, ‘ravage’ and ‘deform’, and relentlessly to consume flesh with insatiable rapacity.